Transporters Revealed
نویسندگان
چکیده
The subfamily C ATP-binding cassette (ABCC) transporters mediate multidrug resistance and ion conductance regulation. Recent atomic or near-atomic resolution structures of three physiologically significant ABCC transporters (MRP1, SUR1, and CFTR), determined by using single-particle cryo-electron microscopy (cryo-EM), reveal structural details that help explain the wide functional diversity of this ABC transporter subfamily.
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عنوان ژورنال:
- Cell
دوره 168 شماره
صفحات -
تاریخ انتشار 2017